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KMID : 0614619930250040709
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Korean Journal of Gastroenterology
1993 Volume.25 No. 4 p.709 ~ p.712
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Effect of Bile Salt Feeding on the Endotoxemia in Rats with Biliary Obstruction
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Abstract
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Preoperative external biliary drainage has been used widely during the past years to decrease the operative mortality and morbidity of patients with obstructive jaundice. However, several controlled studies have reported no benefit from
preoperative
biliary drainage. The filure to decrease the morbidity and mortality of operations after preoperative biliary drainage could be due to the persistence of endotoxemia. The porpose of this study, therefore, is to evaluate systemic endotoxemia occur
in
rats with obstructive jaundice and-to-determine if there is a change in endotoxemia after oral administration of the bile salts.
Experiments using animals showed that the absence of bile salts in the intestinal tract in rats with obstructive jaundice allows endotoxin to be absorbed, and that this absorption can be prevented by the oral administration of bile salts.
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